Intermittent hypoxia increases Rho kinase‐mediated myofilament Ca2+ sensitization in small pulmonary arteries
نویسندگان
چکیده
منابع مشابه
Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries.
Myogenic tone in the pulmonary vasculature of normoxic adult animals is minimal or nonexistent. Whereas chronic hypoxia (CH) increases basal tone in pulmonary arteries, it is unclear if a portion of this elevated tone is due to development of myogenicity. Since basal arterial RhoA activity and Rho kinase (ROK) expression are augmented by CH, we hypothesized that CH elicits myogenic reactivity i...
متن کاملMyofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.
In human cardiomyopathy, anatomical abnormalities such as hypertrophy and fibrosis contribute to the risk of ventricular arrhythmias and sudden death. Here we have shown that increased myofilament Ca2+ sensitivity, also a common feature in both inherited and acquired human cardiomyopathies, created arrhythmia susceptibility in mice, even in the absence of anatomical abnormalities. In mice expre...
متن کاملReactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.
Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced pulmonary hypertension. Endothelin (ET)-1 contributes to the pulmonary hypertensive response to CH, and recent studies by our laboratory and others indicate that pulmonary vascular reactivity following CH is largely independent of ...
متن کاملIntermittent Hypoxia-Induced Sensitization of Central Chemoreceptors
26 Hypertension elicited by chronic intermittent hypoxia (CIH) is associated with elevated 27 activity of the thoracic sympathetic nerve (tSN) that exhibits an enhanced respiratory modulation 28 reflecting a strengthened interaction between respiratory and sympathetic networks within the 29 brainstem. Expiration is a passive process except for special metabolic conditions as hypercapnia 30 when...
متن کاملIntermittent hypoxia in rats reduces activation of Ca2+ sparks in mesenteric arteries.
Ca(+) sparks are vascular smooth muscle cell (VSMC) Ca(2+)-release events that are mediated by ryanodine receptors (RyR) and promote vasodilation by activating large-conductance Ca(2+)-activated potassium channels and inhibiting myogenic tone. We have previously reported that exposing rats to intermittent hypoxia (IH) to simulate sleep apnea augments myogenic tone in mesenteric arteries through...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1438-b